Sondoks 10 tab
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Sondoks
Indications Periodic and transient insomnia.
Doxylamine succinate is a blocker of H1-histamine receptors of the ethanolamine class, which exhibits sedative and anticholinergic effects. It has been demonstrated to reduce the time required to fall asleep, as well as to improve the duration and quality of sleep.
Pharmacokinetics
The maximum concentration in the blood plasma (Cmax) is reached on average after 2 hours (Tmax) following the administration of doxylamine succinate. The average half-life (T½) in plasma is approximately 10 hours. Doxylamine succinate is partially metabolized in the liver by dimethylation and N-acetylation. The half-life may be significantly increased in elderly individuals or patients with renal or hepatic insufficiency. Various metabolites formed during molecule breakdown are not quantitatively significant, as 60% of the administered dose is excreted in the urine in the form of unchanged doxylamine.
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