Rectally.
Acute respiratory viral infections, including influenza, including those complicated by bacterial infection, in children and adults as part of complex therapy.
Adults, including pregnant women, and children over 7 years old
1 suppository 500,000 IU 2 times a day (every 12 hours) daily for 5 days.
Children under 7 years of age, including newborns and premature infants with a gestational age of more than 34 weeks, 1 suppository of 150,000 IU 2 times a day (every 12 hours) daily for 5 days.
Premature newborns with a gestational age of less than 34 weeks: 1 suppository of 150,000 IU 3 times a day (every 8 hours) daily for 5 days.
Children with an increased risk of complications and a long course of the disease (see “Special Instructions”) aged 1 month to 3 years, 1 suppository 500,000 IU 2 times a day (every 12 hours) daily for 5 days, then 1 suppository 150,000 IU 2 times a day (every 12 hours) daily for the next 5 days. Children from 3 years to 7 years: 1 suppository 500,000 IU 2 times a day (every 12 hours) daily for 5 days, then in the morning 1 suppository 500,000 IU and after 12 hours 1 suppository 150,000 IU daily for the next 5 days . For children from 7 years to 18 years old, in the morning, 1 suppository of 1,000,000 IU, then after 12 hours, 1 suppository of 500,000 IU daily for 5 days, then 1 suppository of 500,000 IU 2 times a day (every
12 hours) daily for the next 5 days.
Infectious and inflammatory diseases of newborns, including premature babies: pneumonia (bacterial, viral, chlamydial), meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis) as part of complex therapy.
For newborns, including premature babies with a gestational age of more than 34 weeks, 1 suppository of 150,000 IU 2 times a day (every 12 hours) daily. The course of treatment is 5 days.
Premature newborns with a gestational age of less than 34 weeks: 1 suppository 150,000 IU 3 times a day (every
8 hours) daily. The course of treatment is 5 days.
Recommended number of courses for various infectious and inflammatory diseases: sepsis - 2-3 courses, pneumonia, meningitis -
1-2 courses, herpetic infection - 2 courses, enterovirus infection -
1-2 courses, cytomegalovirus infection - 2-3 courses, mycoplasmosis, candidiasis, including visceral - 2-3 courses. The break between courses is 5 days. According to clinical indications, therapy can be continued.
Chronic viral hepatitis B, C, D in children and adults as part of complex therapy, including in combination with the use of plasmapheresis and hemosorption for chronic viral hepatitis of pronounced activity, complicated by cirrhosis of the liver.
Adults: 1 suppository 3,000,000 IU 2 times a day (every 12 hours) daily for 10 days, then every other day (three times a week) for 6-12 months. The duration of treatment is determined by clinical effectiveness and laboratory parameters.
Children under 6 months of age: 300,000-500,000 IU per day; at the age of 6 months to 12 months – 500,000 IU per day.
Children aged 1 to 7 years: 3,000,000 IU per 1 m2 of body surface area per day.
For children over 7 years old, 5,000,000 IU per 1 m2 of body surface area per day.
The drug is used 2 times a day (every 12 hours) daily for 10 days, then every other day (three times a week) for
6-12 months The duration of treatment is determined by clinical effectiveness and laboratory parameters.
The daily dose of the drug for each patient is calculated by multiplying the recommended dose for a given age by the body surface area calculated using the nomogram for calculating body surface area by height and weight according to Garford, Terry and Rourke. The calculation of a single dose is carried out by dividing the calculated daily dose into 2 administrations, the resulting value is rounded up to the dosage of the suppository.
In case of chronic viral hepatitis of severe activity and liver cirrhosis, before plasmapheresis and/or hemosorption, children under 7 years of age should take 1 suppository of 150,000 IU 2 times a day (every 12 hours) daily for 14 days. Children over 7 years of age: 1 suppository of 500,000 IU 2 times a day (every 12 hours) daily for 14 days.
Infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults, including pregnant women, as part of complex therapy.
Adults: 1 suppository 500,000 IU 2 times a day (every
12 hours) daily for 5-10 days. According to clinical indications, therapy can be continued.
Pregnant women from the second trimester of pregnancy (from the 14th week of gestation) take 1 suppository of 500,000 IU 2 times a day (every 12 hours) daily for 10 days, then at intervals of 3 days (every fourth day) for 9 days. Then every 4 weeks until delivery, 1 suppository of 150,000 IU 2 times a day (every 12 hours) daily for 5 days. Before delivery (from 38 weeks of gestation) to
1 suppository 500,000 IU 2 times a day (every 12 hours) daily for 10 days.
Primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild to moderate course, including the urogenital form in adults, including pregnant women.
Adults: 1 suppository 1,000,000 IU 2 times a day (every 12 hours) daily for 10 days. According to clinical indications, therapy can be continued. It is recommended to begin treatment immediately when the first signs of the disease appear (itching, burning, redness of the skin and mucous membranes). When treating recurrent herpes, it is advisable to begin treatment in the prodromal period or at the very beginning of signs of relapse.
Pregnant women from the second trimester of pregnancy (from the 14th week of gestation) take 1 suppository of 500,000 IU 2 times a day (every 12 hours) daily for 10 days, then at intervals of 3 days (every fourth day) for 9 days. Then every 4 weeks until delivery, 1 suppository of 150,000 IU 2 times a day (every 12 hours) daily for 5 days. Before delivery (from the 38th week of gestation) 1 suppository of 500,000 IU 2 times a day (every 12 hours) daily for 10 days.
Viral meningitis in children over 4 years of age as part of complex therapy.
Children from 4 years to 11 years inclusive: 1 suppository 1,000,000 IU 2 times a day (every 12 hours) daily for
7 days, then 1 suppository 1,000,000 IU 1 time per day (at night) daily for 7 days.
Children from 12 years to 18 years inclusive: 1 suppository 3,000,000 IU 2 times a day (every 12 hours) daily for
7 days, then 1 suppository 3,000,000 IU 1 time per day (at night) daily for 7 days.
Chronic bacterial prostatitis in adults as part of complex therapy.
Adults: 1 suppository 1,000,000 IU 2 times a day (every 12 hours) daily for 20 days.
