From the digestive system: NSAID gastropathy - abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding; Possible irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, hepatitis.
From the respiratory system: shortness of breath, bronchospasm.
From the senses: hearing loss, ringing or noise in the ears, toxic damage to the optic nerve, blurred vision or double vision, scotoma, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin).
From the nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).
From the cardiovascular system: heart failure, tachycardia, increased blood pressure.
From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: skin rash (usually erythematous or urticarial), skin itching, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (syndrome) Lyell), eosinophilia, allergic rhinitis.
From the hematopoietic system: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
From laboratory parameters: possible increase in bleeding time, decrease in serum glucose concentration, decrease in creatinine clearance, decrease in hematocrit or hemoglobin, increase in serum creatinine concentration, increase in the activity of liver transaminases.
With long-term use of the drug in high doses, the risk of developing ulcerations of the gastrointestinal mucosa, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), and visual impairment (impaired color vision, scotoma, damage to the optic nerve) increases.
Contraindications for use
erosive and ulcerative diseases of the organs: gastrointestinal tract (including peptic ulcer of the stomach and duodenum in the acute phase, Crohn's disease, UC);
"aspirin triad";
hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
bleeding of various etiologies;
deficiency of glucose-6-phosphate dehydrogenase;
optic nerve diseases;
pregnancy;
lactation period;
children under 12 years of age;
hypersensitivity to the components of the drug;
history of hypersensitivity to acetylsalicylic acid or other NSAIDs.
The medicine should be used with caution in the following cases: old age; heart failure; arterial hypertension; liver cirrhosis with portal hypertension; liver and/or renal failure, nephrotic syndrome, hyperbilirubinemia; peptic ulcer of the stomach and duodenum (history), gastritis, enteritis, colitis; blood diseases of unknown etiology (leukopenia and anemia).
Use during pregnancy and breastfeeding
There are no adequate and strictly controlled studies of the safety of ibuprofen during pregnancy. The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
The use of ibuprofen may negatively affect female fertility and is not recommended for women planning pregnancy.
Use for liver dysfunction
The medicine should be used with caution in case of liver failure.
Use for renal impairment
The medicine should be used with caution in case of renal failure.
Use in children
Use is contraindicated in children under 12 years of age.
Use in elderly patients
Should be used with caution in old age.
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