Use during pregnancy and breastfeeding
Pregnancy:
There is insufficient data regarding the use of ambroxol during pregnancy. In particular, this applies to the first 28 weeks of pregnancy. Animal studies have not revealed a teratogenic effect.
The use of Ambrobene during pregnancy (II-III trimester) is possible only as prescribed by a doctor, after a careful assessment of the risk/benefit ratio.
Breastfeeding period:
Animal studies have shown that ambroxol passes into breast milk. Due to insufficient study of the use of the drug in women during breastfeeding, the use of Ambrobene is possible only as prescribed by a doctor, after a thorough assessment of the risk/benefit ratio.
Contraindications
- hypersensitivity to ambroxol or one of the excipients;
- pregnancy (first trimester);
- sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
With caution: impaired motor function of the bronchi and increased production of sputum (with fixed cilia syndrome), peptic ulcer of the stomach and duodenum during an exacerbation, pregnancy (II-III trimester), lactation period.
Patients with impaired renal function or severe liver disease should take Ambrobene with extreme caution, observing long intervals between doses or taking the drug in a lower dose.
Side effects
General violations:
Rarely (from ≥ 0.1% to < 1%): allergic reactions (urticaria, skin rash, angioedema of the face, shortness of breath, itching), fever, weakness, headache.
Very rare (<0.01%): anaphylactic reactions, including anaphylactic shock.
From the gastrointestinal tract:
Rarely (from ≥ 0.1% to < 1%): nausea, abdominal pain, vomiting, diarrhea, constipation.
Others:
Rarely (from ≥ 0.1% to < 1%): dryness of the oral mucosa and respiratory tract, exanthema, rhinorrhea, dysuria.
Interaction
With the simultaneous use of ambroxol and antitussives, stagnation of secretions may occur due to suppression of the cough reflex. Therefore, such combinations should be selected with caution. When ambroxol is taken together with the antibiotics amoxicillin, cefuroxime, erythromycin and doxycycline, the concentration of the latter in sputum and bronchial secretions increases.
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