Cefekon D for children aged 3 months to 3 years 100 mg 10 rectal suppositories

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Rectally, after an enema or spontaneous bowel movement. The dosage of Cefekon D is calculated based on age and body weight, according to the table.

The average single dose is 10-15 mg/kg, administered 2-3 times a day every 4-6 hours. The maximum daily dose of paracetamol should not exceed 60 mg/kg.

- 1-3 months (4-6 kg) - 1 suppository of 50 mg (50 mg);
- 3-12 months (7-10 kg) - 1 suppository of 100 mg (100 mg);
- from 1 year to 3 years (11-16 kg) - 1-2 suppositories of 100 mg (100-200 mg);
- from 3 to 10 years (17-30 kg) - 1 suppository of 250 mg (250 mg);
- from 10 to 12 years (31-35 kg) - 2 suppositories of 250 mg (500 mg).

Contraindications:
- Hypersensitivity to the components of Cefecon D;
- Age under 1 month.

Use with caution:
- Impaired liver and kidney function;
- Gilbert's syndrome; Dubin-Johnson and Rotor syndromes;
- Blood disorders (anemia, thrombocytopenia, leukopenia);
- Genetic deficiency of glucose-6-phosphate dehydrogenase enzyme.

Side effects:
Gastrointestinal: nausea, vomiting, abdominal pain.
Allergic reactions: itching, rash on the skin and mucous membranes, urticaria, Quincke's edema.
Hematological: anemia, leukopenia, agranulocytosis, thrombocytopenia.
With prolonged use in high doses: hepatotoxic and nephrotoxic effects (interstitial nephritis, papillary necrosis), hemolytic anemia.

Interactions:
Inducers of microsomal liver oxidation (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol, and hepatotoxic drugs increase the production of hydroxylated active metabolites, leading to the possibility of severe intoxication, even with a small overdose.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects. When taken together with salicylates, the nephrotoxic effect of paracetamol increases. The combination with chloramphenicol leads to an increase in the toxic properties of the latter. It enhances the action of indirect anticoagulants, reduces the effectiveness of uricosuric product.