Ambrobene solution for oral administration and inhalation 100 ml

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How to take, course of administration and dosage
Use of the drug internally

The drug is taken orally after meals, adding to water, juice or tea using the supplied measuring cup.

Children under 2 years of age should take 1 ml of the drug 2 times a day (15 mg ambroxol per day).

Children from 2 to 6 years old should take 1 ml of the drug 3 times a day (22.5 mg ambroxol per day).

Children from 6 to 12 years old should take 2 ml of the drug 2-3 times a day (30 - 45 mg ambroxol per day).

Adults and children over 12 years of age should take 4 ml of the drug 3 times a day (90 mg ambroxol per day) in the first 2-3 days of treatment. If therapy is ineffective, adults can increase the dose to 8 ml of the drug 2 times a day (120 mg ambroxol per day). In the following days, you should take 4 ml of the drug 2 times a day (60 mg ambroxol per day).

Use of the drug in the form of inhalations

When using the drug Ambrobene in the form of inhalations, you can use any modern equipment (except for steam inhalers). Before inhalation, the drug is mixed with a 0.9% sodium chloride solution (for optimal air humidification, it can be diluted in a 1:1 ratio) and heated to body temperature. Since during inhalation therapy, a deep breath can provoke coughing impulses, inhalations should be carried out in normal breathing mode. Patients with bronchial asthma can be recommended to carry out inhalation after taking bronchodilator drugs.

For inhalation, the following dosages are used (1 ml of solution contains 7.5 mg of ambroxol):

children under 2 years of age: 1 ml of solution 1-2 times a day (7.5-15 mg ambroxol per day);

children from 2 to 6 years: 2 ml of solution 1-2 times a day (15-30 mg ambroxol per day);

children over 6 years of age and adults: 2-3 ml of solution 1-2 times a day (15-45 mg ambroxol per day).

The duration of treatment is selected individually depending on the course of the disease. It is not recommended to take Ambrobene for more than 4-5 days without a doctor's prescription.

The mucolytic effect of the drug occurs when taking large amounts of fluid, so drinking plenty of fluids is recommended during treatment.

Overdose
Symptoms. There were no signs of intoxication with an overdose of ambroxol. There are reports of nervous agitation and diarrhea.

Ambroxol is well tolerated when taken orally at doses up to 25 mg/kg/day.

In case of severe overdose, increased salivation, nausea, vomiting, and decreased blood pressure are possible.

Treatment. Intensive therapy methods, such as inducing vomiting and gastric lavage, should be used only in cases of severe overdose, in the first 1-2 hours after taking the drug. Symptomatic treatment is indicated.

Description
A clear, colorless to slightly yellowish-brown solution.
Special instructions
It should not be combined with antitussive drugs that impede the removal of sputum.

In children under 2 years of age, the drug can only be used as prescribed by a doctor. Severe skin reactions, such as Stevens-Johnson syndrome and Lyell's syndrome, have been observed extremely rarely with the use of ambroxol. If there is a change in the skin or mucous membranes, you must immediately consult a doctor and stop taking the drug.

Impact on the ability to drive vehicles and machinery

There have been no studies on the effect of Ambrobene on the ability to drive vehicles and operate machinery. If side effects develop, caution should be exercised when performing actions that require increased concentration and speed of psychomotor reactions.

Use during pregnancy and breastfeeding
Pregnancy. There is insufficient data regarding the use of ambroxol during pregnancy. In particular, this applies to the first 28 weeks of pregnancy. Animal studies have not revealed a teratogenic effect. The use of Ambrobene during pregnancy (II-III trimester) is possible only as prescribed by a doctor, after a thorough assessment of the risk/benefit ratio. Breastfeeding period. Animal studies have shown that ambroxol passes into breast milk. Due to insufficient study of the use of the drug in women during breastfeeding, the use of Ambrobene is possible only as prescribed by a doctor, after a thorough assessment of the risk/benefit ratio.
Contraindications
Hypersensitivity to ambroxol or one of the excipients; pregnancy (first trimester).

Carefully

Impaired bronchial motor function and increased sputum production (with fixed cilia syndrome), peptic ulcer of the stomach and duodenum during an exacerbation, pregnancy (II-III trimester), breastfeeding period.

Patients with impaired renal function or severe liver disease should take Ambrobene with extreme caution, observing long intervals between doses or taking the drug in a lower dose.

Side effects
The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - at least 10%; often – at least 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%.

From the immune system: uncommon - hypersensitivity reaction, frequency not established - anaphylactic reactions, including rash, itching, urticaria, angioedema, anaphylactic shock.

From the nervous system: often - impaired taste perception.

From the gastrointestinal tract: often – nausea; uncommon – dryness of the mucous membrane of the mouth and throat, vomiting, dyspepsia, abdominal pain, diarrhea.

Interaction
With the simultaneous use of ambroxol and antitussives, stagnation of secretions may occur due to suppression of the cough reflex. Such combinations should be selected with caution.

When ambroxol is taken together with the antibiotics amoxicillin, cefuroxime, erythromycin and doxycycline, the concentration of the latter in sputum and bronchial secretions increases.

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