Contraindicated
Increased sensitivity to the components of the drug or to other antihistamines, severe impairment of liver function and/or low function, phenylketonuria, congenital hyperbilirubinemia, deficiency of glucose-6-phosphate dehydro genasis, alcoholism, blood disease, severe anemia, leukopenia, severe arterial hypertension, unstable angina; severe damage to cardiac conduction, acute period of myocardial infarction, severe atherosclerosis, uncompensated heart failure, hyperthyroidism, acute blockage of the section with hypertrophy of the anterior amycholar gland, obstruction cervical mikhur, pyloroduodenal obstruction, vulcanis and duodenum at the stage of constipation, closed cuta glaucoma, thrombosis, thrombophlebitis , epilepsy, severe forms of diabetes. Do not use MAO inhibitors at the same time and for two days after the completion of the MAO inhibitors. Contraindicated for patients taking tricyclic antidepressants or beta blockers. Sechokamyan ailment - for the reason that ascorbic acid is absorbed into the body at a dose of over 1 g per dose.
Childhood up to 6 years of age.
Interactions with other medicinal drugs and other types of interactions
Zapobizhni come in.
Stagnation of sedatives (especially barbiturates) promotes the sedative effect of pheniramine maleate, and therefore, the persistence of such combinations does not occur during the hour of treatment.
Unnecessary combinations.
Due to the presence of pheniramine, ethanol promotes the sedative effect of H1-blockers, so that at the time of treatment, drug constipation is removed, so ethyl alcohol is replaced.
Combinations that should be taken to your esteem.
Due to the presence of pheniramine, other sedatives may cause depression of the central nervous system; These are drugs such as: morphine derivatives (analgesics, cough suppressants, replacement therapy), neuroleptics, barbiturates, benzodiazepines, anxiolytics, drugs, lower benzodiazepines (such as meprobamate), drugs Other drugs, sedative antidepressants (amitriptyline, doxepin, mianserin, mertazapine , trimipramine), sedative H1-blockers, antihypertensive agents of the central nervous system, baclofen and thalidomide.
Due to the presence of pheniramine, there are drugs that can cause atropine-like effects, such as: imipramine antidepressants, most atropine H1-blockers, anticholinergics, antiparkinsonian drugs , atropine antispasmodics, disopramide, phenothiazine antipsychotics and clozapine may cause undesirable atropine effects, such as sore throat, constipation and dryness at the company.
When taken simultaneously with oral anticoagulants, there is an increased risk of their action and increased risk of bleeding when taking paracetamol at maximum doses
(4 g/product) for at least 4 days. The team regularly checks the INR (International Normalized Relations). If necessary, the dose of the oral anticoagulant can be adjusted before taking paracetamol and after taking paracetamol.
Taking paracetamol may interfere with blood glucose measurements using the glucose oxidase-peroxidase method with abnormally high concentrations.
Taking paracetamol can affect the results of blood tests using the phosphotungstic acid method.
The liquidity of soaked paracetamol can increase through one-hour infusion with metoclopramide and domperidone and change through infusion with cholestyramine. Barbiturates alter the antipyretic effect of paracetamol.
Anti-drug drugs (including phenytoin, barbiturates, carbamazepine), which stimulate the activity of microsomal enzymes in the liver, can cause the toxic infusion of paracetamol on the liver due to the advanced stage of drug conversion to hepatotoxicity and metabolites. With one-hour infusion of paracetamol with isoniazid, there is a risk of developing hepatotoxic syndrome. Paracetamol reduces the effectiveness of diuretics.
Don't hang out with alcohol all at once.
Ascorbic acid promotes digestion in the intestines, promotes the addition of ethinylestradiol, penicillins, tetracyclines; reduces the level of antipsychotic drugs, phenothiazine-like drugs in the blood. Glucocorticosteroids change the reserves of ascorbic acid. One-time use of ascorbic acid and deferoxamine promotes tissue toxicity of the tissue, especially in heart meat, which can lead to decompensation of the blood circulation system. It can be stopped only 2 years after injecting deferoxamine. Large doses of ascorbic acid alter the effectiveness of tricyclic antidepressants. Absorption of ascorbic acid decreases with one-hour infusion of oral contraceptives, fruit or vegetable juices, and water drinks.
Be careful with one-hour ingestion of paracetamol and flucloxacillin, but one-hour ingestion is associated with metabolic acidosis with a high anionic gap, especially in patients with severe hypertension (“Features of insufficiency”).
Features of good stagnation
In cases of high body temperature or fever, which can be maintained for 3 days after the drug has been infused,
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